Antibiotic Treatment and Long-term Outcomes of Patients With Pseudomyxoma Peritonei of Appendiceal Origin

Inclusion Criteria: * Patients must have measurable pseudomyxoma peritonei from appendiceal origin, confirmed by histology, cytology, or radiographical evidence - * Age ≥ 21 years * Eastern Cooperative Oncology Group (ECOG) performance status score≤2/Karnofsky performance status of (KPS) ≥ 70% (see Appendix B) * Patients must have normal organ and marrow function as defined below: Absolute neutrophil count (ANC) ≥1,000/mm3 Platelets ≥100,000/mm3 Hemoglobin ≥ 8.5 g/dL Renal function: Creatinine ≤1.5 times the upper limit of normal (ULN) or calculated creatinine clearance ≥60ml/min Hepatic function: Bilirubin ≤1.5 times ULN Alanine aminotransferase (ALT) ≤3 times ULN Aspartate aminotransferase (AST) ≤3 times ULN * Ability of subject or Legally Authorized Representative (LAR) to understand and willingness to sign a written informed consent, approved by Mercy Medical Center Institutional Review Board (IRB) * A negative pregnancy test for women of childbearing age with all reproductive organs intact Exclusion Criteria: * Patients receiving any other investigational agents * Presence of other invasive malignancies or evidence of another cancer present within the last 3 years, excluding skin cancer * history of, or known allergic reaction/hypersensitivity to PREVPAC or any component of similar chemical or biologic composition to PREVPAC * Patients \< 21 of age * Pregnancy or lactation at the time of proposed assignment. Pregnant women are excluded from this study because PR…