Stopped: The study was closed due to recruitment limitations
United States24 participantsStarted 2013-09
Plain-language summary
The purpose of this study is to evaluate the efficacy of D-Cycloserine versus placebo treatment in reducing pain from urological chronic pelvic pain syndrome (UCPPS).
Who can participate
Age range18 Years
SexMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Males greater than 18 years of age, with no racial/ethnic restrictions;
* Meets diagnostic criteria for Interstitial Cystitis with Painful Bladder Syndrome (IC/PBS) and/or Chronic Prostatitis with Chronic Pelvic Pain Syndrome (CP/CPPS);
* Reports symptoms of discomfort or pain in the pelvic or abdominal region for at least a 3 mo period within the last 6 mo;
* Must have a Visual Analog Scale (VAS) pain score \>40 mm (of 100 mm maximum) at the baseline visit (UCPPS pain moderate to severe);
* Must be in generally stable health;
* Must be willing to abstain from drinking alcohol during the course of the study;
* Must be able to read and speak English and be willing to read and understand instructions as well as questionnaires;
* Must sign an informed consent document after a complete explanation of the study documenting that they understand the purpose of the study, procedures to be undertaken, possible benefits, potential risks, and are willing to participate.
Exclusion Criteria:
* Urological pain associated with any systemic signs or symptoms, e.g., fever, chills;
* Evidence of a facultative Gram negative or enterococcus with a value of ≥ 100,000 CFU/ml in mid-stream urine (VB2);
* Has a second chronic pain condition (e.g., chronic low back pain, temporomandibular joint syndrome, etc.) that would prevent a clear interpretation of the study results;
* History of tuberculous cystitis, bladder cancer, carcinoma in situ, prostate cancer, or urethral cance…