CompletedNot Applicable

Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism

United States24 participantsStarted 2014-03

Plain-language summary

This is a clinical study comparing targeted levothyroxine dosing based on thyroid anatomy as visualized on ultrasound (normal vs. ectopic/sublingual vs. athyreosis) to empiric levothyroxine dosing in infants with congenital hypothyroidism. Patients enrolled in the study for targeted dosing will be compared to controls obtained by retrospective chart review. The main outcome is to determine if there is a difference in the frequency of over-treatment and under-treatment during the first 6 months of therapy.

Who can participate

Age range2 Weeks

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Newborns diagnosed with congenital hypothyroidism (CH). * Newborns with CH who are treated by a pediatric endocrinologist at Riley Hospital for Children or satellite location. * Newborns with CH who have thyroid imaging performed (thyroid ultrasound or technetium scan) at diagnosis. Exclusion Criteria: * Newborns who do not have CH. * Newborns with CH who have not had thyroid imaging performed at diagnosis.

What they're measuring

Dose Adjustments

Timeframe: 6 months

Trial details

NCT IDNCT02374593

SponsorErica Eugster

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-05

Results submitted2017-06-06

View on ClinicalTrials.gov More Congenital Hypothyroidism trials