Genetics of Hyperuricemia Therapy in Hmong

Inclusion Criteria: * Both parents are Hmong (self report) * Self report history of gout, or * History (within one year) of active use of xanthine oxidase inhibitors, or * Evidence of serum uric acid ≥ 6mg/dL , or * Serum uric acid \< 6mg/dL with history of ≥ 2 gout episodes within the last 6 months * Ability to provide informed consent for participation in the study * Demonstrate understanding of the study procedures and ability to comply with the study drug for the entire length of the study * Ability to obtain permission from treating clinician to allow stopping the drug for 10 days Exclusion Criteria: * Pregnant women or women of childbearing age sexually active and not using any contraception * estimated creatinine clearance (eCrCl) \<30ml/min * Elevated liver enzymes (3 x upper normal limit of liver function tests (AST and ALT)) * Contraindication to receiving allopurinol * Active participation in other clinical trial (or within 30 days)