CompletedNot Applicable

Genetics of Hyperuricemia Therapy in Hmong

United States80 participantsStarted 2014-06

Plain-language summary

To pursue this objective, we will be measuring uric acid at baseline and post 14 days of twice daily allopurinol therapy in 30 Hmong participants with documented gout or hyperuricemia and known genotype for key renal transporters of uric acid.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Both parents are Hmong (self report) * Self report history of gout, or * History (within one year) of active use of xanthine oxidase inhibitors, or * Evidence of serum uric acid ≥ 6mg/dL , or * Serum uric acid \< 6mg/dL with history of ≥ 2 gout episodes within the last 6 months * Ability to provide informed consent for participation in the study * Demonstrate understanding of the study procedures and ability to comply with the study drug for the entire length of the study * Ability to obtain permission from treating clinician to allow stopping the drug for 10 days Exclusion Criteria: * Pregnant women or women of childbearing age sexually active and not using any contraception * estimated creatinine clearance (eCrCl) \<30ml/min * Elevated liver enzymes (3 x upper normal limit of liver function tests (AST and ALT)) * Contraindication to receiving allopurinol * Active participation in other clinical trial (or within 30 days)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Percent change from baseline in serum uric acid

Timeframe: 14 days

Steady state oxipurniol area under the serum concentration-time curve (AUC)

Timeframe: 14 days

Trial details

NCT IDNCT02371421

SponsorUniversity of Minnesota

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-12

View on ClinicalTrials.gov More Hyperuricemia, Gout trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.