Biomarkers to Classify Heart Failure

Inclusion Criteria: * Patients admitted with symptomatic heart failure, diagnosed within 2 years. * Diagnosis of congestive heart failure using the modified Framingham criteria: Simultaneous presence of at least 2 major criteria or 1 major criterion in conjunction with 2 minor criteria or a previous clear diagnosis of heart failure. Major criteria: * Paroxysmal nocturnal dyspnea or orthopnea * Neck vein distention * Rales/Crackles (\>10 cm from base of lungs) * Acute pulmonary edema * S3 gallop * Increased central venous pressure (\>16 cm H2O at right atrium) * Hepatojugular reflux * Weight loss \>4.5 kg in 5 days in response to treatment Echocardiographic left ventricular dysfunction Minor criteria: * Bilateral ankle edema * Nocturnal cough * Dyspnea on exertion * Hepatomegaly * Pleural effusion * Weight loss \>4.5 kg caused by heart failure where factors other than treatment of CHF could have contributed to the weight loss * Tachycardia (heart rate \>120 beats/min) Minor criteria are acceptable only if they cannot be attributed to another medical condition (such as pulmonary hypertension, chronic lung disease, cirrhosis, ascites, or the nephrotic syndrome). Exclusion Criteria: * Patients unable to provide blood sample * Patients unable to provide consent * Patient with life expectancy of less than 6 months, or has major co-morbidities. * Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk becau…