Safety, Tolerability and Efficacy of the Depigmented Modified Allergen Extract of Two Mites in Su… (NCT02340130) | Clinical Trial Compass
CompletedPhase 2
Safety, Tolerability and Efficacy of the Depigmented Modified Allergen Extract of Two Mites in Subjects With Allergic Rhinitis or Rhinoconjunctivitis, With Controlled Allergic Asthma
Spain57 participantsStarted 2014-09
Plain-language summary
This is an open-label, non-controlled, non-randomised, prospective safety study in patients with rhinitis or allergic rhinoconjunctivitis, with controlled asthma, and clinically relevant sensitisation to dust mites from the Pyroglyphidae and Glycyphagidae families.
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion criteria
✓. Subject has provided appropriately signed and dated written informed consent.
✓. Men and women aged 18 years and 70 years of age at Visit 1.
✓. Has an FEV1 value 80% of predicted normal value at Visit 1.
✓. Individuals suffering from perennial allergic rhinitis or rhinoconjunctivitis moderate-severe for at least the preceding year, with controlled asthma, caused by double sensitization against Dermatophagoides pteronyssinus (DPT) and Lepidoglyphus destructor or Dermatophagoides pteronyssinus and Blomia tropicalis.
✓. Patients sensitized to co-allergens such as tree pollen, grasses or weeds, fungi or animal epithelials cannot participate in the study if they are symptomatic.
✓. If a female is of non-childbearing potential, the subject must be postmenopausal for at least 1 year or surgically sterile.
✓. If a female is of childbearing potential, the subject must be non-lactating and non-pregnant and must correctly use an effective method of contraception during the study.
Exclusion criteria
✕. Any contraindication for treatment with allergen specific immunotherapy.
✕. Subjects with a previous history of anaphylaxis.
✕. Patients with hospital admission due to asthma exacerbations within 1 year prior to V1.
✕. Has uncontrolled asthma, according to Global Initiative for Asthma Guidelines (GINA 2010).
What they're measuring
1
Subjects (%) suffering from immediate or delayed systemic grade 2 reactions
Timeframe: Safety: local and systemic adverse reactions (EAACI classification) within 24 and 48 hours after the treatment.
✕. Has acute or chronic inflammatory or infectious airways disease.
✕. Has chronic structural diseases of the affected organ (e.g. eye, nose, lung).
✕. History or presence of confirmed or potential diseases of the immune system including autoimmune diseases and immune deficiencies of actual clinical relevance.