Efficacy of Guided Tissue Regeneration Membrane in the Healing of Apicomarginal Defects

Inclusion Criteria: * Eligibility criteria included apicomarginal communication confined to buccal aspect with a pocket depth (PD) of \>6 mm and recurrent episodes of purulent discharge, teeth with negative response to vitality tests, with radiographic evidence of periapical radiolucencies, failed previous root canal treatment or retreatment at least 1 year previously, and adequate final restoration with no clinical evidence of coronal leakage Exclusion Criteria: * Teeth with vertical root fracture, resorptive processes extending to more than the apical third of the root, and subjects with chronic generalized periodontitis, systemic disease contraindicating surgical procedures, and conditions affecting rate of healing like diabetes and smoking were excluded from the study.