Metabolic Anomolies Associated With the 6 Month Clinical Evolution of Patients Suffering From Mot… (NCT02329626) | Clinical Trial Compass
CompletedNot Applicable
Metabolic Anomolies Associated With the 6 Month Clinical Evolution of Patients Suffering From Motor Conversion Disorder
France20 participantsStarted 2016-01-29
Plain-language summary
The main objective of this study is to make a first evaluation of the relationship between metabolic abnormalities objectified by Positron emission tomography with 2-deoxy-2-\[fluorine-18\]fluoro- D-glucose integrated with computed tomography (PET CT 18 FDH) performed at rest at the onset of symptoms in patients with a first episode of motor conversion disorder and the persistence of a motor disability at 6 months measured by the modified Rankin score (mRS).
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion Criteria:
* The patient must have given free and informed consent and signed the consent
* The patient must be affiliated with or beneficiary of a health insurance plan
* The patient meets DSM-IV criteria for motor conversion disorder (with paralysis, motor weakness or abnormal movements) lasting for less than 1 month and euthymic (HAMD score \< or = 7, as evaluated by a psychiatrist)
* First episode (incident cases)
* The latest symptom dates to within a month
* The patient is not under neuroleptics
Exclusion Criteria:
* The subject is participating in another study
* The subject is in an exclusion period determined by a previous study
* The subject is under judicial protection, guardianship or curatorship
* The subject refuses to sign the consent
* It is not possible to correctly inform the patient
* The patient is pregnant, parturient or she is breastfeeding
* Specialized clinical neurological examination and brain and spinal cord MRI revealed an organic neurological cause
* The subject has a HAMD score \> 7
* The subject currently has manic/hypomanic episode, a diagnosis of substance abuse or dependency (excluding tobacco), a diagnosis of schizophrenia (any time in the past) or chronic neurological disease (active epilepsy, stroke, brain tumor)
* Suicidal or high risk for suicide (according to MINI assessment)
* Contra-indication for a PET scan
* Patient under neuroleptics at inclusion
* The last symptom happened over 1 month ago
* The patient has had previou…
What they're measuring
1
Presence/absence of a modified Ranking score > 1
Timeframe: 6 months
2
Presence/absence of a metabolic anomoly according to PET CT 18 FDG