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Comparison of Different Botulinum Toxin A Injection Patterns in the Treatment of Blepharospasm

China120 participantsStarted 2013-02

Plain-language summary

To evaluate the efficacy of different botulinum toxin A injection patterns in treating benign essential blepharospasm and to compare their influence on condition of eye surface .

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * had a confirmed diagnosis of bilateral BEB * a minimum of 24-week period since the last injection was required for all patients who had previously received multiple injections of BoNT-A. Exclusion Criteria: * blepharospasm of known etiology (caused by medication, injury, etc.) * history of surgical intervention for BEB (myectomy or neurectomy) * current ophthalmologic infection * apraxia of eyelid opening associated with levator palpebrae dysfunction

What they're measuring

Changes of Jankovic rating scale (JRS) from baseline at 1week, 1month and 3 months

Timeframe: 3 months

Changes of lower lid tear meniscus height (TMH) from baseline at 1week, 1month and 3 months

Timeframe: 3 months

Trial details

NCT IDNCT02327728

SponsorYangHui

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-12

Contact for this trial

Hui Yang, MD, PhD

+86 13710584767 yanghui9@hotmail.com

View on ClinicalTrials.gov More Blepharospasm trials