Topical Clobetasol for the Treatment of Toxic Epidermal Necrolysis

Inclusion Criteria: * Characteristic histological findings on diagnostic biopsy * Clinical diagnosis verified by two independent physicians * Greater than 10% affected body surface area (BSA) * Ability to start treatment within seven days or less from the onset of erosions * Actively worsening disease (enlarging area of involvement or new erosions occurring over the last 24 hours) * Patient Body Surface Area (BSA) \> 1.0 m2 * Reproductive age female patients must have a negative pregnancy test prior to enrollment Exclusion Criteria: * Patients will be excluded if they are \< 7 or \> 85 years of age. * Patients who have documented: * Uncontrolled infection (e.g. documented bacteremia) * Malignancy * Known prior immunodeficiency * Pregnancy * Concurrent use of systemic corticosteroids in the burn center greater than or equal to 0.5 mg/kg/day of prednisone or equivalent dose of similar medication. * Greater than 70% eroded skin * SCORETEN score \>3 on hospital admission * Patients will also be excluded if they have: active hepatitis and/or an ALT or AST greater than four times the normal limits, or renal insufficiency with an estimated GFR\<50 mL/min/1.73m2.