FMT for Multidrug Resistant Organism Reversal

Inclusion criteria will include: * Age ≥18 years old. * Outpatient status at time of FMT. * History of at least three recurrent infections due to an MDRO; at least two recurrent, severe infections due to MDRO requiring hospitalization; or at least two recurrent infections due to MDRO for which only antimicrobials with rate limiting toxicities (see above) are available AND the MDRO is likely of enteric origin. Only MDROs of likely enteric origin will be included. * Be without active infection due to the MDRO at the time of FMT. * Not be receiving antimicrobials (therapeutic or suppressive) within 48 hours of FMT. Exclusion criteria will include: * Subjects \<18 years old. * Subjects unable to be seen as an outpatient. * Use of enteral or systemic antimicrobials at time of FMT. * Planned use of enteral or systemic antimicrobials up to 6 months post-FMT. * Pregnancy or inability/unwillingness to use contraceptives. * Recent intra-abdominal surgery * Short gut syndrome * Gastrointestinal motility disorders * Use of medications that affect intestinal motility an inability to cease using those medications at the time of FMT. * Post-allogeneic hematopoietic stem cell transplant recipients with previous or current gastrointestinal graft versus host disease. * ANC \<500/mm3 * HIV+ and not well controlled on antiretroviral therapy, or CD4+ \<200/ mm3 * At increased risk for peritonitis: presence of intra-abdominal devices, receiving peritoneal dialysis, or ascites. * Any acute illne…