The Paediatric EVICEL® Neuro Study

Inclusion Criteria: * Patient undergoing elective or urgent craniotomy/craniectomy for pathological processes in the posterior fossa (such as benign or malignant tumors, vascular malformation, and Chiari 1 malformations) or in the supratentorial region and who are demonstrated to have persistent CSF leakage following primary attempt at suture closure of the dural incision; * Administration of perioperative antibiotic prophylaxis; * Patients who are less than 18 years of age; * Patients who are able and willing to comply with the procedures required by the protocol; * The subject's parent/legal guardian must be willing to give permission for the subject to participate in the trial, and provide written informed consent for the subject. In addition, assent must be obtained from paediatric subjects who possess the intellectual and emotional ability to comprehend the concepts involved in the trial. * Surgical wound classification Class I (refer to Appendix II). Penetration of mastoid air cells during partial mastoidectomy is permitted; * The cuff of native dura along the craniotomy edge on each side is wide enough based on surgeon's judgment to facilitate suturing and to allow for sufficient surface area for adherence of the investigational product. Exclusion Criteria: * Subjects with a dura lesion from a recent surgery that still has the potential for CSF leakage; * Conditions or treatments significantly compromising the immune system (such as AIDS); * Known hypersensitivity t…