CompletedEarly Phase 1

Neuronal Correlates of Altered States of Consciousness

Switzerland24 participantsStarted 2014-12

Plain-language summary

The aim of the present study is to assess the neuronal correlates of alterations in waking consciousness pharmacologically induced by a 5-hydroxytryptamine (HT)2A receptor agonist in healthy subjects using functional magnetic resonance imaging (fMRI).

Who can participate

Age range25 Years – 65 Years

SexALL

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Inclusion criteria

✓. Age between 25 and 65 years
✓. Understanding of the German language
✓. Understanding the procedures and the risks associated with the study
✓. Participants must be willing to adhere to the protocol and sign the consent form
✓. Participants must be willing to refrain from taking illicit psychoactive substances during the study.
✓. Participants must be willing to drink only alcohol-free liquids and no xanthine-containing liquids (such as coffee, black or green tea, red bull, chocolate) after midnight of the evening before the study session, as well as during the study day.
✓. Women of childbearing potential must have a negative pregnancy test at the beginning of the study and before each study session.

Exclusion criteria

✕. Chronic or acute medical condition
✕. Current or previous major psychiatric disorder
✕. Psychotic disorder in first-degree relatives
✕. Illicit substance use (except tetrahydrocannabinol (THC)-containing products) more than 10 times or any time within the previous month.
✕. Pregnant or nursing women.
✕. Participation in another clinical trial (currently or within the last 30 days)

What they're measuring

fMRI brain activity

Timeframe: 1 hour

Trial details

NCT IDNCT02308969

SponsorUniversity Hospital, Basel, Switzerland

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-09

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