Microbiota Restoration Therapy for Recurrent Clostridium Difficile Infection

Inclusion Criteria: * ≥ 18 years * Medical record documentation of recurrent CDI either: a) at least two recurrences after a primary episode and has completed at least two rounds of standard-of-care oral antibiotic therapy or b) has had at least two episodes of severe CDI resulting in hospitalization. * Documented history that the subject's recurrent CDI is controlled while on antibiotics even if the subject is not currently on antibiotics. * A positive stool test for the presence of C. difficile within 60 days prior to enrollment. Exclusion Criteria: * A known history of continued C. difficile diarrhea while taking on a course of antibiotics prescribed for CDI treatment. * Requires antibiotic therapy for a condition other than recurrent CDI. * Previous fecal transplant prior to study enrollment. * History of inflammatory bowel disease (IBD), e.g., ulcerative colitis, Crohn's disease, or microscopic colitis. * History of irritable bowel syndrome (IBS). * History of chronic diarrhea. * History of celiac disease. * Colostomy. * Planned surgery requiring perioperative antibiotics within 6 months of study enrollment. * Life expectancy of \< 12 months. * Compromised immune system.