This study will collect blood samples from healthy volunteers and volunteers with multiple myeloma who are going to get the seasonal flu, pneumonia, haemophilus influenzae B (HIB), and/or meningococcus vaccines. The main goal of the study is to start to identify differences in the immune response between multiple myeloma patients and people who don't have multiple myeloma. We hope this will provide important information about the best way and time to vaccinate multiple myeloma patients to flu, pneumonia, haemophilus influenzae B (HIB), and/or meningococcus .
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Evaluate composition of T cells, B cells, NK cell and monocyte populations from pre-vaccination though 24 weeks post-vaccination
Timeframe: 24 weeks
Measure of interferon -gamma in activated T cells from pre-vaccination though 24 weeks post-vaccination
Timeframe: 24 weeks
Measure of antigen specific B cells from pre-vaccination though 24 weeks post-vaccination
Timeframe: 24 weeks
Total PnC-IgG, IgG2, PnC-IgG1 and IgG3 levels from pre-vaccination though 24 weeks post-vaccination
Timeframe: 24 weeks
Evaluate both FcyRIIa and FcyRIII polymorphisms
Timeframe: up to 24 weeks