UnknownPhase 4

Continuous Femoral Nerve Block Versus Local-wound Infiltration Analgesia For Patients Receiving Total Knee Arthroplasty --- A Randomized Controlled Trial

China320 participantsStarted 2015-01

Plain-language summary

Post-operative pain after total knee arthroplasty is usually severe and impair the functional recovery of operated joints.The purpose of this study is to determine whether post-operative continuous femoral nerve block analgesia is superior to local wound infiltration combined with intravenous patient controlled analgesia in improving joint function and reducing the incidence of chronic post-surgical pain (CPSP).

Who can participate

Age range18 Years – 75 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * men and women over the 18 years and younger than 75 years old who had received selective unilateral knee replacement. Exclusion Criteria: * bilateral knee replacement * the secondary knee revision and knee surgery not interfering with articular joint cavity (wound debridement and suture) * American Society of Anesthesiology (ASA) classification of anesthesia risk IV and V grade; body mass index higher than 35 * coagulation dysfunction, which is assessed by activated partial thromboplastin time (APTT) higher than the upper limit by 10s * prothrombin time (PT) higher than the upper limit by 5s * International Normalized Ratio (INR) higher than 1.3, or any of criteria met above * local infection of puncture sites * neurological diseases * uncontrolled general infection * intra-operative cardiac arrest.

What they're measuring

chronic moderate-to-severe post-surgical pain

Timeframe: 3 months post-operatively

Trial details

NCT IDNCT02284620

SponsorFirst Affiliated Hospital of Chongqing Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07

Contact for this trial

Lihua Peng, MD

+86-23-89011061 plhbest@163.com