Topotecan Using Convection-Enhanced Delivery (CED) in High Grade Glioma

Inclusion Criteria: * Histologically confirmed diagnosis of supratentorial WHO Grade III or IV (High Grade Glioma) that has undergone surgical biopsy or resection followed by adjuvant chemoradiotherapy, that has evidence of recurrence or progression based on imaging studies and a stereotactic biopsy is indicated for confirmation of recurrence/progression * Karnofsky Performance Status 70-100 * MRI demonstration of a stereotactically accessible enhancing mass of less than 40cm3 that does not require resection to relieve clinically significant mass effect * Patient understands the procedures and agrees to comply with the study requirements by providing written informed consent Laboratory values within the following ranges: * Absolute neutrophil count (ANC)≥1,500/microliter * Platelet count≥100,000/microliter * Hemoglobin≥10g/dL * Normal PT/PTT * Estimated glomerular filtration rate (eGFR) of at least 50mL/min Exclusion Criteria: * Patient is mentally or legally incapacitated at the time of the study * Known HIV(+) or has been diagnosed with AIDS * Participation in another investigational drug study in the prior 4 weeks * Positive pregnancy test in a female * Patient, in the opinion of the investigator, is likely to be poorly compliant * Diffuse subependymal or CSF disease * Tumors involving the cerebellum * Tumor enhancement involving both hemispheres * Active infection requiring treatment * Unexplained febrile illness * Radiation or chemotherapy within 4 weeks of enrollme…