H7N9 viruses have caused an outbreak of severe respiratory disease in 2013-2014 in China that affected many older adults. This study will evaluate the safety of and immune response to a live attenuated H7N9 vaccine in adults 50 to 70 years old.
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Frequency of vaccine-related reactogenicity events (REs) that occur during the acute monitoring (inpatient) phase of the study
Timeframe: Measured through Day 37
Area under the curve (AUC) of nasal virus shedding after each dose of vaccine
Timeframe: Measured through Day 180
Development of serum antibody assessed by either hemagglutination inhibition (HAI) or microneutralization (MN) assays following the H7N9 pLAIV or pIIV doses
Timeframe: Measured through Day 180