Double Blind Study to Evaluate the Efficacy of Collagenase Histolyticum in the Treatment of Lipoma

Inclusion Criteria: * 18-75 years of age, of either sex or any race * Clinical history of at least 2 lipomas for at least one year * Lipomas diagnosed as benign * Two lipomas on distinctly separate parts of the body, or on the torso if 30 cm apart, with easily definable edges * Each lipoma is a single mass with easily definable edges * Lipomas are 5 to 24 cm squared * Women of childbearing potential must use an acceptable method of birth control Exclusion Criteria: * Lipomas on the head, neck, hand or foot, or female breast * Women who are nursing or pregnant * Multi-lobular lipomas * Subjects who have received an investigational drug within 30 days before receiving the first dose of study drug in this study * Subjects with a known allergy to collagenase or any of the inactive ingredients in XIAFLEX * Subjects with uncontrolled diabetes, hypertension, or thyroid disease, or any medical condition that would make the subject unsuitable for enrollment * Subjects having prior treatment or trauma of the lipoma that could interfere with study assessments * Subjects with a history of connective tissue diseases, rheumatological diseases * Subjects taking anticoagulants or planning to receive anticoagulants (except for lo dose aspirin and over-the-counter nonsteroidal anti-inflammatory drugs) within 7 days of injection of study drug