Alternative Antibiotic Regime in the Treatment of GAgP

Inclusion Criteria: * The periodontal diagnosis of subjects with GAgP was established on the basis of clinical and radiographic criteria defined by the 1999 International World Workshop for a Classification of Periodontal Diseases and Conditions. * Patients were included if they were between 18 and 35 years of age and otherwise healthy. Exclusion Criteria: * if the patients had any known systemic diseases or conditions that can/could influence the periodontal status (cancer, cardiovascular and respiratory diseases) * history of hepatitis or HIV infection, * immunosuppressive chemotherapy * current pregnancy, planning a pregnancy or lactation * requirement for antibiotic prophylaxis * oral diseases other than GAgP, ongoing orthodontic therapy * a history of antibiotic therapy or periodontal treatment within the preceding six months. * Subjects were excluded if they had known allergies to quinolones or penicillin or metronidazole * Not willing to participate to the study. * Not accept to sign written informed consent