Cortical Metrics in Intervention Trials With Autism Spectrum Disorders

Group 1 Typically Developing Youth: We will recruit 30 typically developing boys 8-12 years old to participate in a screening visit, and two tactile perception sessions (visit 1 and 2). Inclusion Criteria: * Healthy Male Boys ages 8-12 * Normal developmental milestones and school performance * Primary caretaker is able to participate in study appointments as is indicated Exclusion Criteria: * Significant lifetime medical history including non-febrile seizures, neurological problems, psychiatric problems or learning disabilities * Any sensory impairment (i.e. deafness or blindness) * 1st or 2nd degree family members with a history of ASD * 1st or 2nd degree family members with ADHD or other developmental problems * Adverse reaction to dextromethorphan * Inability to successfully complete and fully understand the reaction time subtest (cortical metrics) Group 2 Youth with ASD: 8-12 years old: \> 30 boys will be recruited who have a known or suspected diagnosis of ASD confirmed by DSM-5 checklist and the ADOS-2 at screening. Inclusion Criteria: * Male Boys ages 8-12 with ASD (confirmed by DSM-5 checklist and the ADOS-2) * IQ's should be within the normal range (≥ 70) (by prior testing or Stanford Binet 5 at screening) * Primary caretaker is able to participate in study appointments as is clinically indicated * Ability of child to participate in all aspects of the protocol per investigator clinical judgment Exclusion Criteria: * New educational or behavioral intervention…