Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial

Inclusion Criteria: * Prior signed written informed from family member (no more needed following amendment in July 2016) * 16 years of age or older * Brain death diagnosis * Left ventricular ejection fraction \< 50% determined by transthoracic echocardiography or hemodynamic instability defined as a mean dose of noradrenaline 0.1 mcg/kg/min + vasopressin Exclusion Criteria: * Heart failure history (removed after june 2015) * Chronic exogenous oral T4 or T3 before death (removed after june 2015) * Having received T4 infusion before recruitment(removed after june 2015) * Echographic images not interpretable * Age 75 and older(removed after june 2015) * Prior coronary heart disease defined as prior coronary artery bypass graft or percutaneous coronary intervention (with or without stents)(removed after june 2015)