Doxycycline Treatment in Mild Thyroid-Associated Ophthalmopathy
China100 participantsStarted 2014-07
Plain-language summary
The aim of this study is to evaluate the effects of subantimicrobial dose doxycycline (50 mg/d), administered for 12 weeks, on patients with mild Thyroid-Associated Ophthalmopathy (TAO).
Who can participate
Age range18 Years – 70 Years
SexALL
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Inclusion Criteria:
* Clinical diagnosis of Thyroid-associated ophthalmopathy
* Mild TAO
* Normal serum free thyroxine and free triiodothyronine concentrations
* No previous specific therapy for TAO, except for local measures
* Written informed consent is obtained
Exclusion Criteria:
* Pregnant females as determined by positive (serum or urine) hCG test at screening or prior to dosing, or lactating females
* Uncontrolled diabetes or hypertension
* History of mental / psychiatric disorder
* Hepatic dysfunction (Alb, AST, ALT and Alkaline phosphates levels must be within normal range for eligibility)
* Renal impairment (Urea and Creatinine levels must be within normal range)
* Tetracycline allergy or intolerance