Active — Not RecruitingNot Applicable

Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus

United States96 participantsStarted 2013-10

Plain-language summary

The goal of this study is to test the feasibility and the tolerability of a tethered spectrally encoded confocal microscopy (SECM) capsule and to use it to image the esophagus.

Who can participate

Age range14 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participant must be a healthy volunteer * OR participant must have a suspicion of EoE * OR participant must have a prior clinical suspicion of EoE * Participant must be older than 14 years of age * Participant must be able to give informed consent Exclusion Criteria: * Participants with the inability to swallow pills and capsules. * Esophageal fistula and/or esophageal strictures with a stricture diameter that is smaller than the diameter of the capsule. * Participants with prior endoscopic ablation or resection treatment of Barrett's Esophagus (BE)

What they're measuring

SECM Imaging quality. Assessed qualitative values like resolution, tissue architecture, background scatter etc.

Timeframe: A single 20 minute visit (5-7 minute imaging).

Tolerability of SECM Capsule Imaging Procedure in Healthy and EoE Participant, measured by feedback scores.

Timeframe: Questionnaire adminstered directly after the imaging portion has been completed.

Trial details

NCT IDNCT02202590

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

View on ClinicalTrials.gov More Eosinophilic Esophagitis trials