Kidney Disease and Ultrasound Imaging (NCT02201537) | Clinical Trial Compass
CompletedNot Applicable
Kidney Disease and Ultrasound Imaging
France141 participantsStarted 2013-03-19
Plain-language summary
The hypothesis of our study is that a correlation exists between the couple ultrasound elastography- renal perfusion estimated with contrast-enhanced ultrasound and the degree of fibrosis estimated in a semi-quantitative way in 4 stages (0; 25 %; 25-50 %; \> 50 %), as elastography alone did not allow to differentiate moderated fibrosis at 3 months in our feasibility study.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Age ≥ 18 years;
* Patient with informed consent;
* Recipient of a living donor graft or cadaveric donor patient;
* No contraindication for biopsy of the graft;
* No contraindication to the injection of SonoVue ®:
* hypersensitivity to sulfur hexafluoride
* acute coronary syndrome, unstable ischemic heart disease (myocardial infarction phase formation or evolution, typical resting angina in the previous 7 days, significant worsening of cardiac symptoms in the previous 7 days, recent intervention on the coronary arteries or another factor suggesting clinical instability (eg, recent deterioration of ECG changes in clinical or laboratory parameters), acute heart failure, stage III or IV heart failure, severe arrhythmias.
* right-left shunt, severe pulmonary hypertension (PAP\> 90 mmHg), uncontrolled systemic hypertension, respiratory distress syndrome
* Affiliated to a social security scheme
Exclusion Criteria:
* Refusal to participate in the study;
* Inability / refusal to give informed consent;
* contraindication for biopsy testing graft;
* Presence of a contraindication to the injection of SonoVue ®.
* Presence of a peripheral venous access in a non-restricted already infused patient, not pickable under ultrasound
* Breastfeeding, pregnancy