Tofacitnib for the Treatment of Alopecia Areata and Variants

Inclusion Criteria: * Age \>= 18 years old * Diagnosis of alopecia areata with \>50% scalp involvement, alopecia totalis, or alopecia universalis * Hair loss present for at least 6 months * No treatment for alopecia areata in past 2 months * No evidence of hair regrowth * Females of childbearing potential must use birth control while taking the medication and there must be a negative pregnancy test documented prior to starting the medication Exclusion Criteria: * Age \<18 years old * Patients have received treatment known to affect alopecia areata within 2 months of enrolling in the study * Patients with a history of malignancy (except history of successfully treated basal cell or squamous cell carcinoma of the skin) * Patients known to be HIV or hepatitis B or C positive * Patients with positive tuberculin skin test or positive QuantiFERON TB test * Patients with leukopenia or anemia * Patients with renal or hepatic impairment * Patients with peptic ulcer disease * Patients taking immunosuppressive medications, including but not limited to prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus, cyclosporine, or TNH-alpha inhibitors * Women of childbearing potential who are unable or unwilling to use birth control while taking the medication * Women who are pregnant or nursing