UnknownPhase 4

Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker

South Korea110 participantsStarted 2013-12

Plain-language summary

1. Adequate sedation with classical sedative agents, propofol 2. Sedation with propofol may induce paradoxical excitement response in heavy alcohol drinkers 3. Dexmedetomidine, α2 receptor agonist, may provide adequate sedation in heavy alcohol drinkers

Who can participate

Age range19 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 19\~65 yr-old patients who is scheduled to undergo knee surgery with regional anesthesia Exclusion Criteria: * History of taking anxiolytics, hypnotics, antiepileptic drugs * Abnormal liver function test (eg: Liver cirrhosis, elevated liver enzymes) * History of allergic reaction with dexmedetomidine or propofol * Contraindication with regional anesthesia * American society of anesthesiologist Physical status III or IV

What they're measuring

Paradoxical excitement response

Timeframe: Every 5 minutes up to 120minutes after drug infusion

Trial details

NCT IDNCT02197403

SponsorChonnam National University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-05-31

View on ClinicalTrials.gov More Anesthesia, Spinal trials