Phase III Radium 223 mCRPC-PEACE III

Exclusion criteria

• ✕. Myocardial infarction within 6 months prior to screening
• ✕. Uncontrolled angina within 3 months prior to screening
• ✕. Congestive heart failure New York Heart Association (NYHA) class III or IV, or patients with history of congestive heart failure NYHA class III or IV in the past, unless a screening echocardiogram or multi-gated acquisition scan (MUGA) performed within 3 months results in a left ventricular ejection fraction that is ≥ 45%
• ✕. History of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes)
• ✕. History of Mobitz II second degree or third degree heart block without a permanent pacemaker in place
• ✕. Uncontrolled hypertension as indicated by a resting systolic blood pressure \> 170 mm Hg or diastolic blood pressure \> 105 mm Hg at screening
• ✕. Hypotension as indicated by systolic blood pressure \< 86 millimeters of mercury (mm Hg) at screening
• ✕. Bradycardia as indicated by a heart rate of \< 45 beats per minute on the screening ECG and on physical examination