CompletedNot Applicable

Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation

South Korea104 participantsStarted 2014-07

Plain-language summary

One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be used during one-lung ventilation. However, there is still a controversy which anesthetic would be more appropriate during one-lung ventilation in the perspective of oxygenation and microcirculation. The investigators hypothesized that intravenous and inhalational anesthetics may affect oxygenation and microcirculation differently during one-lung ventilation.

Who can participate

Age range20 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * undergoing thoracic surgery including one-lung ventilation Exclusion Criteria: * refuse to enroll * BMI over 30 kg/m(2) * severe obstructive or restrictive lung disease * preoperative supplemental oxygen, intubated, or mechanical ventilatory support * preoperative arterial partial pressure of oxygen \< 60 mmHg * pregnancy * history of coronary artery disease * preoperative continuous infusion of vasopressor or inotropes * cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula

What they're measuring

arterial partial pressure of oxygen

Timeframe: 30 min after one-lung ventilation

Trial details

NCT IDNCT02191371

SponsorSeoul National University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-12

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