Inflammation After One Lung Ventilation

Inclusion Criteria: * Patients aged 20-70 years * American Society of Anaesthesiologists (ASA) physical status I-III * elective open lobectomy with OLV Exclusion Criteria: * history of drug hypersensitivity * drug addiction * treatment with psychotropic drugs * severe psychiatric and central nerve system diseases * persistent tobacco abuse, autoimmune system diseases * diabetes mellitus * cardiac failure (New York Heart Association class greater than 2) * clinically relevant obstructive and restrictive lung diseases (vital capacity or forced expiratory volume in 1s lover than 50% of the predicted values) * pulmonary hypertension (mean pulmonary arterial pressure grater than 25 mmHg) * pre-existing coagulation disorders * history of treatment with immunosuppressant drugs in the 4 weeks before surgery * Patient with evidence of pulmonary or systemic infections (C-reactive protein serum concentration greater than 5 mg/L, leucocytosis greater than 10.0 bioparticles/L or body temperature greater than 37 stC) * perioperative blood derivatives, steroids or non-steroidal anti-inflammatory drug (NSAID)