Reward Sensitivity and Pharmacotherapy for Smoking Cessation

Inclusion Criteria: Age: 18-75 years old • Smoking 5 or more cigarettes, Little cigars and/or cigarillos per day, on average, within the 2 months preceding the screening visit and expired CO ≥ 6ppm (if ≤ 5, then NicAlert Strip \>2). * Interested in treatment that might change smoking behavior * Able to follow verbal and written instructions in English and complete all aspects of the study * Provide informed consent and agree to all assessments and study procedures * Have an address and telephone number where they may be reached * Be the only participant in their household Exclusion Criteria: Standard criteria for transdermal nicotine and varenicline smoking cessation trials will be used. Exclusion criteria will include the following: * Within the month immediately preceding the screening visit, use of any form of tobacco products other than cigarettes, little cigars and/or cigarillos on 3 or more days within a week if the individual refuses to refrain from such tobacco use during the course of the study. * Current enrollment or plans to enroll in another smoking cessation program in the next 12 months * Plan to use other nicotine substitutes (i.e., OTC or prescription medication for smoking cessation) or smoking cessation treatments in the next 12 months * Uncontrolled hypertension (SBP greater than 180 or DBP greater than 110) * Reports diagnosis of seizure disorder or a history of neurological illness or closed head injury that in the opinion of the PI feels that it …