Evaluation of G-CSF (Colony Stimulating Factor) in Patients With Chronic Chagas Cardiomyopathy

Inclusion Criteria: * Diagnosis of Chagas' disease confirmed by two serological tests with different methodologies; * Diagnosis of Chagas' cardiomyopathy in NYHA functional classes II, III and IV of heart failure; * Availability and willingness to participate, given the schedule of the study; * Agreement and signing the written form. Exclusion Criteria: * Acute systemic infections * Solid neoplasms, myelodysplastic syndrome, acute or chronic myeloid leukemia, confirmed by imaging studies or past medical history; * Valvulopathies with hemodynamic consequences; * Autoimmune, pulmonary, or degenerative diseases, confirmed by imaging studies or past medical history; * Severe renal, hepatic or thyroid dysfunction, confirmed by imaging studies or past medical history; * Pregnancy (confirmed by examination of β HCG) or lactation; * Known hypersensitivity to G-CSF or to other components of the formula and / or hypersensitivity to proteins derived from E. coli.