Fecal Transplant for Pediatric Patients Who Have Recurrent C-diff Infection

Inclusion Criteria: Recipient inclusion criteria: * Documented laboratory-confirmed clostridium difficile infection * Documentation of ongoing diarrhea at time of recruitment * Children ≥2 years old, \<18 years old; young adults \>18 years old, \<21 years old * Undergoing clinically-indicated colonoscopy * Recurrent c-diff infection (three or more occurrences) Donor inclusion criteria: * First-degree relative recommended, but not compulsory * ≥ 18 years old * In good health * No antibiotic use within the last 90 days * In "low risk" category on modified DHQ (See above) Exclusion Criteria: * Recipient exclusion criteria * Severe comorbid condition (at discretion of the principal investigator) * On immunosuppressive medications (high dose steroids 30 mg/kg of methylprednisolone) * Severe or fulminant C. difficile colitis * Toxic appearance * Signs of hemodynamic instability * Peritoneal signs on physical exam * Anemia on complete blood count * electrolyte imbalances on basic metabolic panel * Considerations for Increased Risk of Adverse Events Should Be Given to patients with decompensated liver cirrhosis, advanced HIV/acquired immune deficiency syndrome, recent bone marrow transplant, or other cause of severe immunodeficiency. * History of severe anaphylactic shock Donor exclusion criteria: * Abnormal stools * Abdominal complaints * History of inflammatory bowel disease or gastrointestinal malignancy * Symptoms indicative of irritable bowel syndrome or other…