Adjuvant Toremifene With or Without Goserrelin in Premenopausal Women With Stage I-IIIA, Hormonal Receptor Positive Breast Cancer Accompanied With or Without Chemotherapy Induced Amenorrhoea

Inclusion Criteria: * Written informed consent must be obtained and documented according to the local regulatory requirements prior to beginning specific protocol procedures * Age of at least 18 and at most 45 years * Spontaneous and regular menstrual periods before study entry with FSH below 15 mlU/ml in follicular phase * Histologically confirmed primary breast cancer with the need for anthracycline-based chemotherapy * Steroid receptor (estrogen and progesterone) positive tumor (diagnosis according to hospital standard-procedures) * No clinical evidence of local recurrence or distant metastases. Complete staging work-up within 3 months prior to registration. All patients must have (bilateral) mammography or breast MRI, chest X-ray; other tests may be performed as clinically indicated * Karnofsky-Index \>80% * Life expectancy of at least 10 years, disregarding the diagnosis of cancer * Adequate organ function including normal red and white blood count, platelets, serum creatinine, bilirubin, and transaminases within normal range of the institution * Patients underwent standard Doxorubicin/Cyclophosphamide Followed by Docetaxel (AC-T) * Patients must be available for and compliant to treatment and follow-up. Patients registered on this trial must be treated and followed up at the participating center. Exclusion Criteria: * Known hypersensitivity reaction to the investigational compounds or incorporated substances * Prior cytotoxic treatment for any reason * Suspected (pri…