Effects of Transcranial Magnetic Stimulation (TMS) on Somatosensory Perception (NCT02119637) | Clinical Trial Compass
CompletedNot Applicable
Effects of Transcranial Magnetic Stimulation (TMS) on Somatosensory Perception
United States40 participantsStarted 2014-04-17
Plain-language summary
Background:
\- Different parts of the brain are involved in feeling touch. Researchers want to study whether repetitive magnetic stimulation (rTMS) to the sensory cortex affects how sensation feels. rTMS is a repeated magnetic pulse that interferes with brain activity. It affects a small part of the brain beneath the scalp. Researchers want to find out the role of sensory cortex in sensing different types of touch.
Objectives:
\- To find out the role of sensory cortex, a brain area, in sensing different types of touch.
Eligibility:
\- Healthy adults ages 18 45.
Design:
* Participants will be pre-screened with a telephone interview. Then they will be screened with physical and psychological exams and a urine test.
* In Session 1, participants will have an MRI brain scan and fill out questionnaires.
* For MRI, a magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder. A coil will be placed over their head. They will perform a task during the scan. The scanner makes loud knocking noises. Participants will get earplugs. They will be in the scanner for up to 60 minutes.
* In Sessions 2 and 3, participants will take urine tests. Their perception of touch will be measured. Then rTMS will be used to stimulate their sensory cortex and scalp for about 20 minutes. Their perception of touch will be measured again.
* For rTMS, a wire coil is held on the scalp. A brief electrical current passes through the coil and creates a magnetic pulse that affects activity in the brain.
Who can participate
Age range18 Years – 45 Years
SexALL
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Inclusion criteria
✓. between 18 and 45 years old
✓. right-handed.
✓. Fluent in English.
✓. able to provide written informed consent.
Exclusion criteria
✕. Has a dermatological condition such as scars, burns, callouses, or tattoos that might influence cutaneous sensibility on the hands
✕. Has had recent or permanent injury of upper limbs or amputation or use of prosthetic arm or leg
✕. Used recreational drugs within the past month
✕. Is pregnant or breastfeeding.
✕. Has a current chronic pain condition or has had chronic pain in the past (painful condition lasting more than six months).
✕. Has a major medical condition, such as kidney, liver, cardiovascular, autonomic, pulmonary, or neurological problems (including blindness or deafness) or a chronic systemic disease (e.g. diabetes).
What they're measuring
1
2-point touch discrimination on hand during active and control rTMS sessions
Timeframe: 2 years
Trial details
NCT IDNCT02119637
SponsorNational Center for Complementary and Integrative Health (NCCIH)
✕. Has a medical condition potentially affecting somatosensation (e.g. Raynaud s Disease, peripheral neuropathy, or circulatory disorder).
✕. Participant has or had psychiatric disorders such as major depression, major anxiety-related problems, substance or alcohol dependence or abuse, post-traumatic stress syndrome, bipolar disorder, psychosis, or suicide attempts or persistent suicide ideation.