Prospective, randomized, controlled, multicenter, international clinical trial. The study population consist of patients with paroxysmal or persistent atrial fibrillation with out range hypertension or signs of sympathetic overdrive. Patient will be randomized into one of the following two groups.
group 1 : patients will undergo pulmonary vein isolation, group 2: Patients will undergo pulmonary vein isolation and renal artery denervation.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. The patient is willing and able to comply with the protocol and has provided written informed consent.
✓. The patient falls within the target group resistant hypertension or sympathetic overdrive
✓. Patient is an acceptable candidate for renal denervation treatment
✓. Patient is \< 65 year of age
Exclusion criteria
✕. Documented left atrial diameter on trans thoracic echocardiography (PLAX \> 4.5 cm).
✕. Contraindication to chronic anticoagulation therapy or heparin.
✕. Previous left heart ablation procedure for AF (atrial fibrillation).
✕. Acute coronary syndrome, cardiac surgery, PCI (percutaneous coronary intervention)or stroke within 3 months prior to enrollment.
✕. Untreated hypothyroidism or hyperthyroidism.
✕
What they're measuring
1
Time to first detection of atrial fibrillation > 30 seconds, with the monitoring period starting 3 months after the intervention.