Active — Not RecruitingNot Applicable

Network Analysis of Urinary Molecular Signature Complements Clinical Data to Predict Postoperative Acute Kidney Injury

United States240 participantsStarted 2015-07

Plain-language summary

The risk for postoperative acute kidney injury (pAKI), as for any other postoperative complications (PC), comes from a number of interactions between a patient's health before surgery, strength to tolerate surgery and influences on the operating room environment. At this time doctors do not have good tools to predict which patients may be at risk of having this complication. The purpose of this research study is to develop a urine test that can be used to predict the risk for having problems with kidney function after major surgery.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria for Surgical Group: * Patients undergoing major in-hospital surgery * Planned hospital stay of at least 24 hours * Able to enroll prior to undergoing surgery Exclusion Criteria for Surgical Group: * Patients not recruited 4 hours prior to undergoing surgery Inclusion Criteria for Healthy volunteers: \> 18 years old that elect to serve as a control group Exclusion Criteria for Healthy volunteers: Renal Replacement Therapy AKI/CKD Nephrectomy Organ transplant Any of the following within the last 12 months: * Stroke/Transient Ischemic Attack * Heart Attack * Major Thoracic, abdominal, or Vascular surgery * Radiation Therapy * Chemo Therapy * Immunosuppressive Therapy IV contrast within the past 72 hours

What they're measuring

Occurrence of postoperative acute kidney injury (pAKI)

Timeframe: up to 7 days after surgery.

Trial details

NCT IDNCT02114138

SponsorUniversity of Florida

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2030-06

View on ClinicalTrials.gov More Acute Kidney Injury trials