Randomized Trial Comparison of Ototoxicity Monitoring Programs

Inclusion Criteria: All Veterans entering cisplatin chemotherapy will be informed of the project and invited to participate unless the Veteran was excluded by CPRS review or medical advice. Exclusion Criteria: * Experimental subjects must be prescribed cisplatin for treatment of cancer to be enrolled in the treatment arms of this study. Criteria for excluding subjects (chemotherapy and controls subjects) from this study will be: * cognitively or physically unable to participate (patient or nurse report patient is incapable of participating), CPRS indication that subject exhibits aggressive behavior, subject has documented dementia, Alzheimer's disease, or severe psychosocial disorder, CPRS notes indicate individual is not legally capable of providing informed consent (subject has a legal guardian) * unable to provide reliable behavioral hearing test responses (for either program evaluation hearing test or baseline, pre -treatment hearing test) as indicated by intra-session behavioral threshold reliability criterion of \> +5 dB) * exhibits Meniere's disease or retrocochlear disorder based on hearing test results, patient report or notes in CPRS * exhibits active or recent history of middle ear disorder based on otoscopy, tympanometry, patient report, or notes in CPRS * unwilling to participate * hearing thresholds \> 70 dB SPL at 4 kHz and below (based on DPOAE 'no response' data from a similar protocol described in Bibliography Reference 32, Table 3). The last exclusion …