Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of mild traumatic brain injury (mTBI).
Who can participate
Age range18 Years – 65 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Adults, 18-65 years old.
✓. One or more mild TBI's due to blunt or blast injury.
✓. Meets criteria for PPCS.
✓. Ability to complete the NSI.
✓. Ability to complete the PCL-M or C.
✓. Ability to complete CAPS if needed.
✓. Absence of acute cardiac arrest or hemorrhagic shock at time of TBI that would cause a global ischemic insult to the TBI.
✓. Ability to complete the Michigan Alcohol Screening Test( MAST) and Drug Abuse Screening Test (DAST).
Exclusion criteria
✕. Pulmonary disease that precludes HBOT (e.g., bronchospasm unresponsive to medication, bullous emphysema).
✕. Unstable medical conditions that are contraindicated in HBOT (e.g. severe congestive heart failure or heart failure requiring hospital emergency evaluation or admission in the previous year).
✕. Severe confinement anxiety (e.g., patients who require anesthesia conscious sedation for MRI).
✕. Other pre-TBI cerebral neurological diagnoses including stroke, dementia, degenerative diseases, multiple sclerosis, congenital neurological disorder.
✕
What they're measuring
1
Working Memory
Timeframe: One week after final HBOT
2
Neurobehavioral Symptom Inventory (NSI)
Timeframe: One week after final HBOT
Trial details
NCT IDNCT02089594
SponsorLouisiana State University Health Sciences Center in New Orleans