CompletedNot Applicable

PICU Transfusion Study: Harmful Effects of Red Blood Cell Transfusions

United States120 participantsStarted 2013-12

Plain-language summary

The investigators hypothesize that the storage-damaged red cells are responsible for some of the adverse effects of transfusion. In this observational study, the investigators will measure various laboratory parameters both before and after transfusion in a pediatric intensive care unit to determine at what duration of storage is there laboratory evidence of refrigerator storage damage. The investigators hypothesize that increasing storage time of packed red blood cells (PRBCs) transfused will be associated with increasing non-transferrin-bound iron (NTBI), pro-inﬂammatory cytokine concentrations, and enhanced microbial growth in vitro in pediatric patients.

Who can participate

Age range21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Less than 21 years of age; * Greater than 5kg weight; * Parents or legal guardian have signed informed consent; * Will be receiving transfusion of packed, leukoreduced RBCs stored in an additive saline (AS) solution (standard practice). Exclusion Criteria: * Patients have undergone transfusion of platelets or fresh frozen plasma 4 hours before or will receive these products after transfusion of the RBC unit; * Transfusion of RBC from more than one donor at the test transfusion event.

What they're measuring

Non-transferrin-bound iron level

Timeframe: Up to 12-hours post-transfusion

Trial details

NCT IDNCT02087553

SponsorColumbia University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2014-10

View on ClinicalTrials.gov More Iron, Abnormal Blood Level trials