Image-guided Cryoablation of Head, Neck and Spine Tumors

Inclusion Criteria: * Participants must meet the following criteria on screening examination to be eligible to participate in the study: * Participants must have histologically confirmed malignant tumor that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective. * Participants with malignant locally recurrent and/or metastatic tumors will be eligible for cryoablation. All tumor shapes and sizes will be eligible for ablation. * Participants must have sustained all available treatment options (radiation, chemotherapy, surgery) as verified by the Dana Farber Cancer Institute's Head and Neck Tumor Board. These cases will be reviewed by a team of medical oncologists, radiologists, radiation oncologists, and surgical oncologists. * Participants must have an advanced head, neck or spine malignant tumor that would potentially benefit from a minimally invasive procedure. * Age 18 years or older \-- Because no dosing or adverse event data are currently available on the use of cryoablation in participants \< 18 years of age, children are excluded from this study but will be eligible for future pediatric III trials. * Life expectancy of greater than 8 weeks in the opinion of the referring clinician. * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 (see Appendix A). * Participants must have normal organ and marrow function as defined below: * Leukocytes ≥ 3,000/microliter (mcL) * Absolute neu…