Role of Vitamin C to Augment Iron Chelation With DFP or DFX

Inclusion Criteria: * • Subjects with overload secondary to thalassemia major Exclusion Criteria: * • with HIV positive or have active HCV. * A history of serious immunologic hypersensitivity to any medication such as anaphylaxis or angioedema. * Participation in a previous investigational drug study within the 30 days preceding screening. * A woman of childbearing potential must have a negative serum pregnancy test at screening. She must use a medically acceptable form of birth control during the study and for a month afterwards who are pregnant or breast-feeding. * An inability to adhere to the designated procedures and restrictions of this protocol.