Study of Tolerability and Efficacy of BVS857 in Severe Burn Subjects

Inclusion Criteria: * Burn injury comprising 2nd degree deep partial thickness and/or 3rd degree full thickness burns, ≥20% total body surface area with expected need for surgical intervention and not exceeding the sum of age plus burn size of 100 (Baux score) * Dosing must occur within 8-12 days post-burn * Subjects must weigh at least 45kgs (for group 1 with doses of 0.03mg/kg) and be under 100 kg to participate in the study Exclusion Criteria: * Spinal cord injury * Hypoxic brain injury (Glasgow Coma Scale (GCS) \<8) at screening * True conductive electric burn with suspected neurologic injury * Uncontrolled diabetes with HbA1c \> 10% at screening, or known history of hypoglycemia, * History of or active peripheral neuropathy or seizure disorder * Systemic corticosteroids : \> 10mg/d of prednisone or equivalent, other investigational treatments (excluding investigational dressings), medications for weight loss including megestrol acetate, androgens or oral beta agonists