Effect of AKB-6548 on Cardiac Repolarization Intervals in Healthy Volunteers

Key Inclusion Criteria: * Healthy, non-smoking males or females, 18 and 55 years of age, inclusive * BMI 18.0 and 32.0 kg/m2, inclusive * non clinically significant 12-lead ECG * heart rate of 45 to 90 beats per minute, inclusive * mean systolic blood pressure \<141 mmHg and mean diastolic blood pressure \< 90 mmHg Key Exclusion Criteria: * history or presence of significant cardiovascular, pulmonary, hepatic, renal, hematologic, GI, endocrine, immunologic, dermatologic, neurologic, or psychiatric disease * history of unexplained syncope, cardiac arrest, unexplained cardiac arrhythmias, or torsades de pointes, structural heart disease, or a family history of Long QT syndrome * significant abnormalities in liver function tests * history of stomach or intestinal surgery or resection that would potentially alter absorption and/or excretion of orally administered drugs * history of Gilbert's Syndrome * positive hepatitis panel * seizure disorder or receiving anti-epilepsy medication for seizure disorder * any acute or chronic condition that, in the opinion of the Investigator, may pose a safety risk to a subject in this study or which would limit the subject's ability to complete and/or participate in this clinical study