The purpose of this study evaluate the effect of the method of administration of autologous bone marrow mononuclear cells for the duration of of functioning aorto-coronary bypass grafts in the surgical treatment of coronary heart disease, to assess the degree of effectiveness depending on the method of transplantation (intramyocardial, intracoronary, combined).
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Assessment of the Initial Risk of Surgery (EuroScore II).
Timeframe: Before CABG surgery at baseline.
Length of Hospital Stay. Length of Stay in the Intensive Care Unit.
Timeframe: Primary hospitalization for planned CABG.
The Severity of the Systemic Inflammatory Response in the Postoperative Period (Leukocytosis).
Timeframe: The parameters were evaluated initially at baseline in the postoperative period - an interval of 0-6 hours, 12-18 hours, 18-24 hours, 48 hours, 72 hours, 96 hours, 7 days and 14 days.
Assessment of the Degree of General Inflammatory Response (C-reactive Protein (CRP)),
Timeframe: Initial data, control point in the interval 4-6 days of the postoperative period, control point in the interval 12-14 days of the postoperative period.
The Volume of Discharge Through the Drains in the Early Postoperative Period.
Timeframe: Evaluation of these data - for the time spent in the intensive care unit before removing the drains.
Dynamics of Markers of Myocardial Damage (Troponin I, Myoglobin).
Timeframe: 1 and 3 days of the postoperative period.
Dynamics of Markers of Myocardial Damage (Creatine Phosphokinase Fraction MB (CPK-MB)).
Timeframe: 1 and 3 days of the postoperative period.
Intraoperative Assessment of Homeostasis (Hemoglobin (Hb).
Timeframe: Intraoperative data.
Intraoperative Assessment of Homeostasis (Hematocrit (HCT)).
Timeframe: Intraoperative data.
Intraoperative Assessment of Homeostasis (Đš+).
Timeframe: Intraoperative data.
Cardiopulmonary Bypass Time.
Timeframe: Intraoperative data.
Time of Aortic Clamping (Anoxia).
Timeframe: Intraoperative data.
Assessment of Complications in the Postoperative Period. Additional Estimation of Safety.
Timeframe: Postoperative period.
Left Ventricular Ejection Fraction - Echocardiography - Assessment of Myocardial Contractility on Days 7-14 After Surgical Treatment. Additional Estimation of Safety.
Timeframe: 7-14 days of the postoperative period
Assessment of Myocardial Contractility on Days 7-14 After Surgical Treatment - Echocardiography (Size of the Left Ventricle - Index). Additional Estimation of Safety.
Timeframe: 7-14 days after surgery
Volume of the Left Ventricle - Index - Echocardiography. Assessment of Myocardial Contractility on Days 7-14 After Surgical Treatment. Additional Estimation of Safety.
Timeframe: 7-14 days after surgery
Restoration of the Heart Rate After the Completion of the Main Stage of the Surgical Intervention. Additional Estimation of Safety.
Timeframe: Upon completion of the main stage of surgery.