Study to Evaluate the Food Effect of Single-dose Bioavailability of Pracinostat in Healthy Adult Subjects

Inclusion Criteria: * Healthy, adult, male or female, 18-55 years of age, inclusive, at screening. * Cohort 1 only: continuous nonsmoker who has not used nicotine-containing products for at least 6 months prior to the first dose and confirmed by urine cotinine test at screening. * Cohort 2 only: moderate to heavy smokers defined as \> 1 pack of cigarettes per day or \> 39 cigarettes per week for at least 6 months prior to the first dose and confirmed by urine cotinine test at screening. * Body Mass Index (BMI) ≥ 18.5 and ≤ 32.0 kg/m2 at screening. * Medically healthy with no clinically significant medical history, physical examination, laboratory profiles, vital signs or ECGs, as deemed by the PI. * For a female of non-childbearing potential: * A non vasectomized, male subject must agree to use a condom with spermicide or abstain from sexual intercourse during the study until 90 days beyond the last dose of study medication. (No restrictions are required for a vasectomized male provided his vasectomy has been performed 4 months or more prior to study start. A male who has been vasectomized less than 4 months prior to study start must follow the same restrictions as a non vasectomized male). * Understands the study procedures in the informed consent form (ICF), and be willing and able to comply with the protocol Exclusion Criteria: * Subject is mentally or legally incapacitated or has significant emotional problems at the time of screening visit or expected during the condu…