Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder

Inclusion Criteria: * Male or Female (Women of child bearing potential must be non-pregnant, non-lactating and agree to be on an acceptable method of contraception.) * Age 21 to 55 years, inclusive. * In good general physical health as determined by medical history, a baseline physical examination, vital signs, clinical laboratory tests and electrocardiogram (EKG) measurement. * Current IED by DSM-5 * LHA-Aggression ≥ 12. * OAS-M Irritability score ≥ 6, and OAS-M Total Aggression score ≥ 15, respectively at Visit 1 * Mean Irritability and Total Aggression scores for Visit 2 and Visit 3, ≥ 6 and ≥ 15, respectively. * Subject is willing and able to sign written informed consent prior to receipt of any study medication or beginning study procedures. * Subject is willing and able to follow instructions, comply with the protocol requirements and make all required study visits. Exclusion Criteria: * Subject with a positive test for alcohol and/or drugs of abuse at screening or at any time during the study. * Presence of any of the following serious and active medical conditions: Seizure Disorder (n.b.: history of \< 2 febrile seizures prior to one year of age is acceptable); Demyelinating or Progressive Degenerative Disorders; central nervous system (CNS) Infection; Progressive Degenerative Neurological Disorder; Ischemic Heart Disease, Respiratory Disease, Renal Disease; Liver Disease; Type I Diabetes; Malignant Neoplasm; Hyper- or Hypo-Coagulopathy; Acquired Immuno-Deficiency …