Randomized Controlled Trial of Aspirin vs Placebo in the Treatment of Pre-psychosis

Inclusion Criteria: * Age 19 - 35 * Must have a SIPS interview * CHR subjects must meet at least one of 3 CHR syndromes defined by SIPS * Must demonstrate adequate decisional capacity Exclusion Criteria: * Under age of 19 * Have pre-existing gastrointestinal disease, heart disease * Have kidney disease * Taking non-steroidal anti-inflammatory medications * Hypersensitive to NSAID (non-steroidal anti-inflammatory medications) * Have coexisting unstable major medical illness * Are pregnant or breastfeeding * Consume more than 2 drinks of alcohol per day * Have a blood clotting disorder * Are taking ACE inhibitors, acetazolamide, anticoagulants, anticonvulsants, beta blockers, diuretics, methotrexate, oral hypoglycemic or uricosuric agents * Have a history of substance abuse in past three moths or dependence in past 6 months