Protein Intake on Muscle Protein Synthesis Overnight (NCT02041143) | Clinical Trial Compass
CompletedPhase 1
Protein Intake on Muscle Protein Synthesis Overnight
Switzerland17 participantsStarted 2014-02
Plain-language summary
This trial is an exploratory study in order to determine whether the ingestion of one type of protein (milk protein/CHO/Fat) vs.placebo (CHO/Fat) 2 hours before bed time results in the extension of the post-prandial window of anabolism during the night by increasing whole body protein balance as well as muscle protein fractional synthesis rate (FSR).
Who can participate
Age range55 Years – 65 Years
SexMALE
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Inclusion Criteria:
* Male
* Healthy as determined by the medical questionnaire and the medical visit including blood sampling
* 55-65y of age
* BMI (19.0 - 25.0 kg/ m²)
* Having signed the consent form
Exclusion Criteria:
* Digestive (intestinal, gastric, hepatic or pancreatic), renal or metabolic disease, as determined by the medical (screening) visit and a blood chemistry analysis (glucose, total cholesterol, LDL, HDL, triglycerides, aspartate transaminase, alanine aminotransferase, gamma glutamyl transpeptidase, C Reactive Protein, creatinin)
* Heart or other organ disease
* Arterial hypertension (Systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg)
* Any clotting trouble (diagnosed by Prothrombin time (PT), activated Partial Thromboplastin Time (aPTT), fibrinogen measures and platelets number (the latter is part of a classical blood cells counting at screening)
* Any inflammatory disease in the past four weeks
* Use of specific medications
* Recent major surgery (3 months)
* History of major gastro-intestinal surgery (gastric bypass, intestinal resection etc…)
* History of cancer within the past year
* Significant weight loss during the last 3 months (5% and more)
* Food allergies, especially cow milk protein allergies
* Special diets especially vegetarian, high protein or weight loss program (anamnesis)
* Smokers
* High level structured exercise 3 times a week (e.g.: fitness club, competitions…)
* Have a high alcohol consumption (more than 2 drinks/day)
* Co…