Phase II/III Study of the Safety and Effectiveness of HRIG With Active Rabies Vaccine in Healthy Subjects

Inclusion Criteria: * Able and willing to sign an informed consent. * Healthy male or female subjects of 18 - 75 years of age inclusive who have not previously been immunized against rabies. * Ability to comply with completion of a home diary. * No previous exposure to Rabies epidemic, Rabies vaccine and/or Rabies Immune globulin. * No significant abnormalities in serum hematology, serum chemistry and serum immunogenic markers (C3, C4 and C50) according to the Principal Investigator's judgment. * No significant abnormalities in urinalysis according to the Principal Investigator's judgment. * No significant abnormalities in ECG per investigator judgment. * Non-pregnant, non-lactating female subjects, whose screening pregnancy test is negative and who are using contraceptive methods deemed reliable by the investigator, or who are more than 5 years post-menopausal or surgically sterilized. * Male subjects must be using at least one effective contraceptive method before study start and throughout the entire duration of the study. Exclusion Criteria: * History or laboratory evidence of immunoglobulin A deficiency. * A history of previous administration of rabies vaccine or HRIG. * History of live virus vaccine administration, e.g., measles vaccine, within the last 3 months. * History of anaphylactic or anaphylactoid hypersensitivity reactions to chicken egg; history of mild allergic reactions to chicken egg, e.g., skin rash only, is not an exclusion criterion * History of hyper…